Test Bank For Pharmacotherapeutics for Nurse Practitioner Prescribers 3rd Edition by Teri Moser Woo
Chapter 2: Review of Basic Principles of Pharmacology
Multiple Choice
Identify the choice that best completes the statement or answers the question.
____ 1. A patient’s nutritional intake and lab work reflects hypoalbuminemia. This is critical to prescribing because:
A. | Distribution of drugs to target tissue may be affected |
B. | The solubility of the drug will not match the site of absorption |
C. | There will be less free drug available to generate an effect |
D. | Drugs bound to albumin are readily excreted by the kidney |
____ 2. Drugs that have a significant first-pass effect:
A. | Must be given by the enteral (oral) route only |
B. | Bypass the hepatic circulation |
C. | Are rapidly metabolized by the liver and may have little if any desired action |
D. | Are converted by the liver to more active and fat-soluble forms |
____ 3. The route of excretion of a volatile drug will likely be:
A. | The kidneys |
B. | The lungs |
C. | The bile and feces |
D. | The skin |
____ 4. Medroxyprogesterone (Depo Provera) is prescribed IM to create a storage reservoir of the drug. Storage reservoirs:
A. | Assure that the drug will reach its intended target tissue |
B. | Are the reason for giving loading doses |
C. | Increase the length of time a drug is available and active |
D. | Are most common in collagen tissues |
____ 5. The NP chooses to give cephalexin every 8 hours based on knowledge of the drug’s:
A. | Propensity to go to the target receptor |
B. | Biological half-life |
C. | Pharmacodynamics |
D. | Safety and side effects |
____ 6. Azithromycin dosing requires the first day’s dose be twice those of the other 4 days of the prescription. This is considered a loading dose. A loading dose:
A. | Rapidly achieves drug levels in the therapeutic range |
B. | Requires four to five half-lives to attain |
C. | Is influenced by renal function |
D. | Is directly related to the drug circulating to the target tissues |
____ 7. The point in time on the drug concentration curve that indicates the first sign of a therapeutic effect is the:
A. | Minimum adverse effect level |
B. | Peak of action |
C. | Onset of action |
D. | Therapeutic range |
____ 8. Phenytoin requires a trough level be drawn. Peak and trough levels are done:
A. | When the drug has a wide therapeutic range |
B. | When the drug will be administered for a short time only |
C. | When there is a high correlation between the dose and saturation of receptor sites |
D. | To determine if a drug is in the therapeutic range |
____ 9. A laboratory result indicates the peak level for a drug is above the minimum toxic concentration. This means that the:
A. | Concentration will produce therapeutic effects |
B. | Concentration will produce an adverse response |
C. | Time between doses must be shortened |
D. | Duration of action of the drug is too long |
____ 10. Drugs that are receptor agonists may demonstrate what property?
A. | Irreversible binding to the drug receptor site |
B. | Up-regulation with chronic use |
C. | Desensitization or down-regulation with continuous use |
D. | Inverse relationship between drug concentration and drug action |
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